Aurora kinases: A novel target for drug development
نویسندگان
چکیده
منابع مشابه
Aurora kinases as an anti-cancer target.
The Aurora family of serine/threonine kinases plays an important role in chromosome alignment, segregation and cytokinesis during mitosis. Recent studies have found aberrant expression of Aurora kinases in a variety of human solid tumors and hematological malignancies, suggesting they have a role in carcinogenesis. This review highlights the function of Aurora kinases in the regulation of mitos...
متن کاملAurora kinases as anticancer drug targets.
The human aurora family of serine-threonine kinases comprises three members, which act in concert with many other proteins to control chromosome assembly and segregation during mitosis. Aurora dysfunction can cause aneuploidy, mitotic arrest, and cell death. Aurora kinases are strongly expressed in a broad range of cancer types. Aurora A expression in tumors is often associated with gene amplif...
متن کاملAurora kinases: novel therapy targets in cancers
Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via regulating mitosis especially the process of chromosomal segregation. Besides regulating mitosis, Aurora kinases have been implicated in regulating meiosis. The deletion of Aurora kinases could lead to failure of cell division a...
متن کاملpyridoindoles , novel inhibitors of the Aurora kinases
Aurora kinases are serine/threonine protein kinases that are involved in cancer development and are important targets for cancer therapy. By high throughput screening of a chemical library we found that benzo[e]pyridoindole derivatives inhibited Aurora kinase. The most potent compound (compound 1) was found to be an ATP competitive inhibitor, which inhibited in vitro Aurora kinases at the nanom...
متن کاملAurora kinases
to relinquish its shell, allowing the attacker to evict it by pulling it out through the aperture; or the attacker may give up, and release the defender, without effecting an eviction. If the attacker is successful, it will perform the usual investigatory activities on the vacated shell and decide whether to occupy it permanently. During this process the evicted defender is left without a shell...
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ژورنال
عنوان ژورنال: Health Science Inquiry
سال: 2011
ISSN: 2562-7791
DOI: 10.29173/hsi52